High-dosage vitamin E supplementation and all-cause mortality.

Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality.

BACKGROUND Experimental models and observational studies suggest that vitamin E supplementation may prevent cardiovascular disease and cancer. However, several trials of high-dosage vitamin E supplementation showed non-statistically significant increases in total mortality. PURPOSE To perform a meta-analysis of the dose-response relationship between vitamin E supplementation and total mortali...

Review: high dose vitamin E supplementation is associated with increased all cause mortality.

Impact of vitamin A supplementation on infant and childhood mortality

INTRODUCTION Vitamin A is important for the integrity and regeneration of respiratory and gastrointestinal epithelia and is involved in regulating human immune function. It has been shown previously that vitamin A has a preventive effect on all-cause and disease specific mortality in children under five. The purpose of this paper was to get a point estimate of efficacy of vitamin A supplementat...

Antioxidant vitamins and the prevention of coronary heart disease.

Clinical use of antioxidant vitamin supplementation may help to prevent coronary heart disease (CHD). Epidemiologic studies find lower CHD morbidity and mortality in persons who consume larger quantities of antioxidants in foods or supplements. Clinical trials indicate that supplementation with certain nutrients is beneficial in reducing the incidence of CHD events. Recent studies show that sup...

Vitamin E and coronary artery disease.

Various studies have evaluated the antioxidant effects of vitamin E in the prevention or treatment of coronary artery disease (CAD). In vitro data suggest that vitamin E protects against oxidation of low-density lipoprotein and decreases the deposition of atherogenic oxidized low-density lipoprotein in arterial walls. Various observational and epidemiological studies also suggest a relationship...